ABSTRACT
Abstract@#Adolescent idiopathic scoliosis (AIS) is the most common type of spinal deformity, which progress rapidly in adolescence. Patients without intervention can cause serious cardiopulmonary diseases as well as physical and mental health problem. Early screening and intervention can reduce probability that progress to operation and improve the prognosis. At present, China has not carried out extensive screening for scoliosis, and has not developed a unified screening standard, resulting in cross sectional comparison between various studies. The article focuses on the current situation of adolescent scoliosis research and the dispute of screening and puts forward suggestions.
ABSTRACT
@#Ideal osseointegration is intimately related to favorable osteoimmune properties around dental implants. An increasing number of in vitro and in vivo studies have indicated that the Hippo-YAP signaling pathway is involved in this biological process. In this article, the implicated roles of Hippo-YAP the signaling axis in peri-implant osteoimmunology were summarized by reviewing relevant evolving literature. The discrepancy concerning the Hippo-YAP signaling regulatory effect on osteogenesis and polarization direction were analyzed as well as propose the potential mechanism, which may be caused by the maturation of osteogenesis-related cells and heterogeneity of macrophages. More attention should be given to the requirements of promoting osteogenesis and patterns of regulating the immune microenvironment by Hippo-YAP in future studies.